Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PDE2A | O00408 | 2/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | PPARD | Q03181 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.45 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402762 | 0.99 | NPC1 (0.53) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3402982 | 0.93 | SMYD2 (0.53) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3405595 | 0.92 | PDE2A (0.47) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3403787 | 0.92 | SMYD2 (0.50) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3401250 | 0.91 | PDE2A (0.47) | NPC1ALDH1A1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3405826 | 0.88 | DPP4 (0.49) | ALDH1A1PDE2APDE10ACHRM4NPSR1 | |
| SCHEMBL3400943 | 0.88 | DPP4 (0.56) | ALDH1A1MAPTPPARACHRM4CACNA1G | |
| SCHEMBL3398247 | 0.87 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2PDE2APDE10ACHRM4 | |
| SCHEMBL3401355 | 0.87 | DPP4 (0.54) | ALDH1A1MAPTSMN1; SMN2PDE2APDE10A | |
| SCHEMBL3401847 | 0.86 | HTR2C (0.45) | NPC1SMN1; SMN2PDE2APDE10ACHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |