Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.51 |
| ▸ | HTR6 | P50406 | 4/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | HTR1A | P08908 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR5A | P47898 | 2/20 | 0.45 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.45 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL252278 | 0.83 | DRD2 (0.60) | ADRB1HTR6HTR1AHTR2AHTR1D | |
| SCHEMBL13533082 | 0.76 | ADRB1 (0.56) | ADRB1HTR6HTR7HTR1AHTR2A | |
| SCHEMBL5480657 | 0.75 | ADRB1 (0.63) | ADRB1HTR6HTR7HTR1AHTR2A | |
| SCHEMBL15834279 | 0.70 | ADRB1 (0.75) | ADRB1HTR6HTR7HTR1AHTR2A | |
| SCHEMBL13672075 | 0.69 | DRD2 (0.53) | ADRB1HTR6HTR7HTR1AHTR2A | |
| SCHEMBL12907049 | 0.69 | ADRB1 (0.51) | ADRB1HTR6HTR7HTR1AHTR2A | |
| SCHEMBL13672065 | 0.69 | DRD2 (0.53) | ADRB1HTR7HTR1AHTR2ADRD2 | |
| Eltoprazine SCHEMBL177715 | 0.68 | ADRB1 (1.00) | ADRB1HTR1AHTR2ASIGMAR1ALDH1A1 | |
| SCHEMBL6266386 | 0.68 | ADRB1 (0.77) | ADRB1HTR6HTR7HTR1AHTR2A | |
| SCHEMBL3569730 | 0.68 | ADRB1 (0.54) | ADRB1HTR6HTR7HTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003418-A2 | FUNCTIONALLY SELECTIVE LIGANDS OF DOPAMINE D2 RECEPTORS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2012-01-05 | — | — | WO | disclosed |