Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 5/20 | 0.63 |
| ▸ | DRD2 | P14416 | 4/20 | 0.56 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 8/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.45 |
| ▸ | HTR3B | O95264 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | HTR3A | P46098 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13533082 | 0.86 | ADRB1 (0.56) | ADRB1DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL30659425 | 0.84 | DRD2 (0.53) | ADRB1DRD2HTR1AHTR6 | |
| SCHEMBL26953448 | 0.81 | DRD2 (0.51) | ADRB1DRD2HTR1AHTR2ADRD3 | |
| Eltoprazine SCHEMBL1651102 | 0.78 | ADRB1 (0.94) | ADRB1DRD2HTR1AHTR2ADRD3 | |
| Eltoprazine SCHEMBL177715 | 0.78 | ADRB1 (1.00) | ADRB1DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL3615477 | 0.77 | ADRB1 (0.61) | ADRB1DRD2HTR1AHTR2ADRD3 | |
| Eltoprazine SCHEMBL679616 | 0.76 | ADRB1 (0.97) | ADRB1DRD2HTR1AHTR2ADRD3 | |
| Eltoprazine SCHEMBL31235563 | 0.76 | ADRB1 (0.97) | ADRB1DRD2HTR1AHTR2ADRD3 | |
| Eltoprazine SCHEMBL29438749 | 0.76 | ADRB1 (0.97) | ADRB1DRD2HTR1AHTR2ADRD3 | |
| SCHEMBL3605711 | 0.76 | ADRB1 (0.65) | ADRB1DRD2HTR1AHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202241-B2 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050124613-A1 | Benzoxazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2005-06-09 | — | — | US | disclosed |
| EP-0138280-B1 | BLOOD-PRESSURE LOWERING PIPERAZINE DERIVATIVES | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1988-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050124613-A1 | Benzoxazine derivatives and uses thereof | XDH, CYP4X1, CYP2C9 | ADRB1 224/4885DRD2 983/4885HTR1A 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.