Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.55 |
| ▸ | HTR2B | P41595 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL212928 | 0.91 | HTR2C (0.59) | HTR2CHTR2BALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL521854 | 0.87 | LTA4H (0.63) | ALDH1A1TSHRSMN1; SMN2NPSR1KDM4E | |
| SCHEMBL2085669 | 0.86 | SYK (0.58) | HTR2CHTR2BTSHRKDM4ESYK | |
| SCHEMBL12448367 | 0.85 | AXL (0.61) | HTR2CHTR2BALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL3401694 | 0.81 | ALDH1A1 (0.54) | HTR2CHTR2BALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL2230279 | 0.81 | ALDH1A1 (0.65) | HTR2BALDH1A1TSHRSMN1; SMN2NPSR1 | |
| SCHEMBL1667163 | 0.80 | AXL (0.61) | HTR2BALDH1A1TSHRSMN1; SMN2NPSR1 | |
| SCHEMBL12312257 | 0.80 | ALDH1A1 (0.58) | HTR2CHTR2BALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL13791083 | 0.80 | SYK (0.59) | HTR2CHTR2BALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL1929865 | 0.79 | HTR2C (0.58) | HTR2CHTR2BSMN1; SMN2KDM4ELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |