Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FSCN1 | Q16658 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401819 | 1.00 | FSCN1 (0.41) | FSCN1SMN1; SMN2HPGDNPC1RAB9A | |
| SCHEMBL1642844 | 0.80 | CYP2B6 (0.41) | SMN1; SMN2HPGDNPC1ALDH1A1GAA | |
| SCHEMBL10053417 | 0.77 | ALDH1A1 (0.41) | HPGDPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3288030 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2TP53ALDH1A1LMNATSHR | |
| SCHEMBL1134230 | 0.72 | SMN1; SMN2 (0.43) | SMN1; SMN2TP53ALDH1A1LMNATSHR | |
| SCHEMBL7442872 | 0.72 | BACE1 (0.39) | HPGDALDH1A1KDM4E | |
| SCHEMBL2257344 | 0.71 | CYP3A4 (0.43) | RAB9AALDH1A1GAAMAPTLMNA | |
| SCHEMBL2257347 | 0.71 | CYP3A4 (0.43) | RAB9AALDH1A1GAAMAPTLMNA | |
| SCHEMBL6273809 | 0.71 | MAPT (0.52) | SMN1; SMN2HPGDNPC1RAB9ANLRP1 | |
| SCHEMBL4539730 | 0.71 | LMNA (0.34) | SMN1; SMN2ALDH1A1GAALMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250155-A1 | 5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009089462-A1 | 5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |