Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 4/20 | 0.34 |
| ▸ | MAOA | P21397 | 4/20 | 0.34 |
| ▸ | MAOB | P27338 | 4/20 | 0.34 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394805 | 0.88 | TRPA1 (0.39) | DDB1CRBNSLC18A3SIGMAR1PRCP | |
| SCHEMBL9420060 | 0.78 | PRCP (0.40) | SLC18A3SIGMAR1PRCPMEN1KMT2A | |
| SCHEMBL31266435 | 0.75 | KDM4E (0.40) | PRCPMEN1KMT2AKDM1AMAOA | |
| SCHEMBL18801244 | 0.71 | TRPA1 (0.35) | SLC18A3SIGMAR1PRCPMEN1KMT2A | |
| SCHEMBL8926653 | 0.71 | TRPA1 (0.38) | KDM1AMAOAMAOB | |
| SCHEMBL31504308 | 0.71 | TRPA1 (0.45) | PRCPKDM1AMAOAMAOB | |
| SCHEMBL30298452 | 0.70 | CHRNB2 (0.59) | SLC18A3SIGMAR1PRCPMEN1KMT2A | |
| SCHEMBL172454 | 0.70 | CHRNB2 (0.59) | SLC18A3SIGMAR1PRCPMEN1KMT2A | |
| SCHEMBL1413442 | 0.70 | CHRNB2 (0.59) | SLC18A3SIGMAR1PRCPMEN1KMT2A | |
| SCHEMBL38664211 | 0.68 | DDB1 (0.39) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |