Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | MGLL | Q99685 | 2/20 | 0.50 |
| ▸ | PHGDH | O43175 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19070596 | 0.84 | SMN1; SMN2 (0.77) | SMN1; SMN2AKR1C3PHGDHRAB9AHPGD | |
| SCHEMBL15023275 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2POLBRAB9AKMT2AMEN1 | |
| SCHEMBL16464172 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2MGLLPOLBRAB9AKMT2A | |
| SCHEMBL16625322 | 0.76 | HSD11B1 (0.38) | POLBRAB9AKMT2AMEN1NPC1 | |
| SCHEMBL17796641 | 0.76 | AKR1C3 (0.52) | SMN1; SMN2AKR1C3PHGDHPOLBRAB9A | |
| SCHEMBL28941604 | 0.74 | SMN1; SMN2 (0.56) | SMN1; SMN2MGLLRAB9AKMT2AMEN1 | |
| SCHEMBL28770085 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9AKMT2AMEN1NPC1 | |
| SCHEMBL12477371 | 0.72 | ALDH1A1 (0.55) | SMN1; SMN2AKR1C3RAB9AKMT2AMEN1 | |
| SCHEMBL12477377 | 0.72 | ALDH1A1 (0.55) | SMN1; SMN2AKR1C3RAB9AKMT2AMEN1 | |
| SCHEMBL18644455 | 0.72 | RAB9A (0.58) | SMN1; SMN2AKR1C3POLBRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | disclosed |