Pyrrolidine

Pyrrolidine

SCHEMBL3402069

C1CCNC1.NC(=O)Cl

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Azepane SCHEMBL9671876 0.97 ALDH1A1 (0.53)
Piperidine SCHEMBL4603677 0.97 ALDH1A1 (0.53)
Pyrrolidine SCHEMBL1800837 0.87
Piperazine SCHEMBL4823909 0.87 MAPT (0.43)
Pyrrolidine SCHEMBL1202575 0.87
Pyrrolidine SCHEMBL28527711 0.87 ALDH1A1 (0.53)
Piperidine SCHEMBL2675445 0.84 ALDH1A1 (0.60)
Piperidine SCHEMBL3283269 0.84 ALDH1A1 (0.60)
Piperazine SCHEMBL3258524 0.84 MAPT (0.40)
Pyrrolidine SCHEMBL15387295 0.84 ALDH1A1 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2250167-A1 ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS Chlorion Pharma, Inc. (CA) 2010-11-17 EP disclosed
US-20090275538-A1 ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS UNIVERSITE LAVAL (CA) 2009-11-05 US disclosed
WO-2009097695-A1 ARYLMETHYLIDENE HETEROCYCLES AS NOVEL ANALGESICS CHLORION PHARMA, INC. (CA) 2009-08-13 WO disclosed
EP-0813867-B1 Retroviral protease inhibitors MONSANTO CO (US) 2005-06-01 EP disclosed
US-6420418-B1 INHIBITION AND PREVENTION OF LEUKOCYTE ADHESION; USED TO TREAT ADHESION-MEDIATED DISEASES SUCH AS ASTHMA, ALLERGIC RHINITIS, MULTIPLE SCLEROSIS; ATHEROSCLEROSIS, AND INFLAMMATORY BOWEL DISEASE MERCK & CO., INC. 2002-07-16 US disclosed
US-6353099-B1 USED FOR PREVENTION OR TREATMENT OF DISEASES, DISORDERS, CONDITIONS OR SYMPTOMS MEDIATED BY CELL ADHESION IN MAMMAL MERCK & CO., INC. 2002-03-05 US disclosed
WO-2001014328-A2 SUBSTITUTED UREAS AS CELL ADHESION INHIBITORS MERCK & CO., INC. (US) 2001-03-01 WO disclosed
WO-2001012183-A1 HETEROCYCLE AMIDES AS CELL ADHESION INHIBITORS MERCK & CO., INC. (US) 2001-02-22 WO disclosed
EP-0558630-B1 RETROVIRAL PROTEASE INHIBITORS MONSANTO CO (US) 1998-04-08 EP disclosed
US-5708004-A ENZYME INHIBITORS FOR TREATMENT OF AIDS MONSANTO COMPANY (US) 1998-01-13 US disclosed
US-4883831-A STABILIZERS CONTAIN TETRAALKYL PIPERIDINE UNITS ICI AMERICAS INC. (US) 1989-11-28 US disclosed
US-4851461-A PHOTOSTABILIZERS ICI AMERICAS INC. (US) 1989-07-25 US disclosed
EP-0291239-A2 Glutarate based stabilisers for plastics ICI AMERICAS INC. (US) 1988-11-17 EP disclosed
US-4701485-A Malonate-based light stabilizers for plastics ICI AMERICAS INC. (US) 1987-10-20 US disclosed
EP-0220034-A2 Malonate derivatives useful as light stabilizers for plastics ICI AMERICAS INC. (US) 1987-04-29 EP disclosed
US-4507291-A Arthropod repellents ROHM AND HAAS COMPANY (US) 1985-03-26 US disclosed
US-4405630-A AZASPIRO COMPOUNDS ROHM AND HAAS COMPANY (US) 1983-09-20 US disclosed
US-4400512-A INSECT REPELLENTS ROHM AND HAAS COMPANY (US) 1983-08-23 US disclosed
US-4374991-A INSECT REPELLENTS ROHM AND HAAS COMPANY (US) 1983-02-22 US disclosed
US-4357471-A INSECT REPELLENTS ROHM AND HAAS COMPANY (US) 1982-11-02 US disclosed