Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL3258524 | 0.97 | MAPT (0.40) | MAPTHIF1APDE4AKDRKDM4E | |
| Pyrrolidine SCHEMBL3402069 | 0.87 | — | — | |
| Piperazine SCHEMBL1613092 | 0.85 | MAPT (0.50) | MAPTHIF1APDE4AKDRKDM4E | |
| Piperazine SCHEMBL3987157 | 0.85 | HIF1A (0.50) | MAPTHIF1APDE4AKDRKDM4E | |
| Piperazine SCHEMBL4778411 | 0.85 | MAPT (0.50) | MAPTHIF1APDE4AKDRKDM4E | |
| Piperidine SCHEMBL4603677 | 0.84 | ALDH1A1 (0.53) | MAPTKDM4EKMT2ACXCR4SMN1; SMN2 | |
| Azepane SCHEMBL9671876 | 0.84 | ALDH1A1 (0.53) | MAPTKDM4EKMT2ACXCR4SMN1; SMN2 | |
| Piperazine SCHEMBL11443166 | 0.81 | MAPT (0.46) | MAPTHIF1APDE4AKDRKDM4E | |
| Piperazine SCHEMBL250578 | 0.81 | ACHE (0.54) | MAPTHIF1APDE4AKDRKDM4E | |
| Piperazine SCHEMBL3992732 | 0.81 | HIF1A (0.46) | MAPTHIF1APDE4AKDRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456173-B2 | Compositions comprising zopiclone derivatives and methods of making and using the same | SEPRACOR INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-7189715-B2 | Compositions comprising zopiclone derivatives and methods of making and using the same | SEPRACOR INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-20070049590-A1 | Compositions comprising zopiclone derivatives and methods of making and using the same | ALTER DOMUS (US) LLC | 2007-03-01 | — | — | US | disclosed |
| US-20040147521-A1 | Compositions comprising zopiclone derivatives and methods of making and using the same | ALTER DOMUS (US) LLC | 2004-07-29 | — | — | US | disclosed |
| WO-2004037212-A2 | COMPOSITIONS COMPRISING ZOPICLONE DERIVATIVES AND METHODS OF MAKING AND USING THE SAME | SEPRACOR, INC. (US) | 2004-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049590-A1 | Compositions comprising zopiclone derivatives and methods of making and using the same | CYP51A1, CYP3A43, HSD17B7 | MAPT 1700/4885HIF1A 3990/4885PDE4A 1089/4885 |
| US-20040147521-A1 | Compositions comprising zopiclone derivatives and methods of making and using the same | CYP51A1, CYP3A43, CYP4A11 | MAPT 1769/4885HIF1A 3694/4885PDE4A 1226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.