Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.46 |
| ▸ | DRD3 | P35462 | 7/20 | 0.44 |
| ▸ | DRD4 | P21917 | 5/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 5/20 | 0.43 |
| ▸ | DRD1 | P21728 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | HTR2B | P41595 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403050 | 0.90 | TMEM97 (0.49) | DRD2DRD3DRD4SMYD2KMT2A | |
| SCHEMBL3399682 | 0.90 | DRD2 (0.49) | DRD2DRD3DRD4SMYD2HTR1A | |
| SCHEMBL3404517 | 0.88 | F10 (0.47) | DRD2DRD3DRD4SMYD2ADRA1D | |
| SCHEMBL3402585 | 0.88 | DRD2 (0.47) | DRD2DRD3DRD4SMYD2HTR1A | |
| SCHEMBL3405123 | 0.86 | HTR3A (0.55) | DRD2DRD3DRD4SMYD2HTR1A | |
| SCHEMBL3404939 | 0.84 | HDAC3 (0.49) | DRD2DRD3DRD4SMYD2HTR1A | |
| SCHEMBL3399769 | 0.84 | DRD2 (0.48) | DRD2DRD3DRD4SMYD2 | |
| SCHEMBL13071564 | 0.83 | DRD2 (0.47) | DRD2DRD3DRD4SMYD2 | |
| SCHEMBL3401391 | 0.82 | DRD2 (0.44) | DRD2DRD3DRD4SMYD2HTR1A | |
| SCHEMBL3402142 | 0.81 | CD274 (0.48) | DRD2DRD3DRD4LMNAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |