Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.49 |
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404939 | 0.93 | HDAC3 (0.49) | DRD2DRD3HTR1AHTR2ASMYD2 | |
| SCHEMBL3403050 | 0.93 | TMEM97 (0.49) | DRD2DRD3SMYD2DRD4MAPT | |
| SCHEMBL3404517 | 0.91 | F10 (0.47) | DRD2DRD3SMYD2DRD4HTR3A | |
| SCHEMBL3402585 | 0.91 | DRD2 (0.47) | DRD2DRD3HTR1AHTR2ASMYD2 | |
| SCHEMBL3402102 | 0.90 | DRD2 (0.46) | DRD2DRD3HTR1AHTR2ASMYD2 | |
| SCHEMBL3405123 | 0.89 | HTR3A (0.55) | DRD2DRD3HTR1AHTR2ASMYD2 | |
| SCHEMBL3399769 | 0.87 | DRD2 (0.48) | DRD2DRD3SMYD2DRD4HTR3A | |
| SCHEMBL3401183 | 0.86 | MAPT (0.49) | DRD2DRD3HTR1AHTR2ASMYD2 | |
| SCHEMBL13071564 | 0.86 | DRD2 (0.47) | DRD2DRD3SMYD2DRD4HTR3A | |
| SCHEMBL3404897 | 0.85 | ACHE (0.54) | DRD3SMYD2MAPTTHRBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |