Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.54 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.53 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | THRA | P10827 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.48 |
| ▸ | ACACA | Q13085 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13072174 | 1.00 | TDP1 (0.54) | TDP1HRH3TRPM8HTR2CCNR1 | |
| SCHEMBL3398926 | 0.91 | TRPM8 (0.54) | HRH3TRPM8HTR2CCNR1THRA | |
| SCHEMBL13309716 | 0.90 | HRH3 (0.56) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3405666 | 0.90 | HRH3 (0.56) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3404811 | 0.90 | HRH3 (0.51) | TDP1HRH3HTR2CCNR1THRA | |
| SCHEMBL3400894 | 0.90 | HRH3 (0.51) | TDP1HRH3HTR2CCNR1THRA | |
| SCHEMBL13071715 | 0.88 | HRH3 (0.67) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3402620 | 0.88 | THRA (0.52) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3403838 | 0.88 | HRH3 (0.67) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3399868 | 0.88 | THRA (0.52) | HRH3HTR2CCNR1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |