Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.46 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399993 | 0.90 | HTR2C (0.50) | HTR2CSLC29A1CES2CNR1KDM4E | |
| SCHEMBL3404735 | 0.89 | HTR2C (0.48) | HTR2CCES2CNR1KDM4EALDH1A1 | |
| SCHEMBL3398622 | 0.87 | HTR2C (0.47) | HTR2CCES2CNR1ALDH1A1 | |
| SCHEMBL3402322 | 0.85 | CNR1 (0.46) | HTR2CDRD2CNR1DRD3KDM4E | |
| SCHEMBL3406091 | 0.85 | HTR2C (0.42) | HTR2CSLC29A1CES2KDM4EALDH1A1 | |
| SCHEMBL3403060 | 0.85 | LMNA (0.40) | HTR2CSLC29A1CES2DRD2DRD3 | |
| SCHEMBL3398386 | 0.85 | THRA (0.43) | HTR2CSLC29A1CES2CNR1DRD3 | |
| SCHEMBL3403442 | 0.85 | HTR2C (0.43) | HTR2CSLC29A1CES2DRD2CNR1 | |
| SCHEMBL13310335 | 0.85 | HTR2C (0.43) | HTR2CSLC29A1CES2DRD2DRD3 | |
| SCHEMBL3401274 | 0.84 | SLC29A1 (0.47) | SLC29A1HTR2ACNR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |