Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400762 | 0.93 | POLB (0.45) | CNR1POLBMAPTKMT2AMEN1 | |
| SCHEMBL3402959 | 0.91 | HRH3 (0.46) | CNR1MAPTKMT2AMEN1HTR2C | |
| SCHEMBL3405886 | 0.91 | CNR1 (0.43) | CNR1POLBMAPTKMT2AMEN1 | |
| SCHEMBL3405569 | 0.90 | CNR1 (0.48) | CNR1MAPTKMT2AMEN1HTR2C | |
| SCHEMBL3404063 | 0.88 | TRPM8 (0.50) | CNR1MAPTHTR2CTHRATHRB | |
| SCHEMBL3405405 | 0.88 | KMT2A (0.53) | CNR1MAPTKMT2AMEN1HTR2C | |
| SCHEMBL3402239 | 0.88 | CNR1 (0.49) | CNR1KMT2AHTR2CNPC1HPGD | |
| SCHEMBL3405513 | 0.88 | HRH3 (0.49) | CNR1KMT2AMEN1HTR2CALDH1A1 | |
| SCHEMBL3401176 | 0.88 | CNR1 (0.60) | CNR1MAPTHTR2CALDH1A1NPC1 | |
| SCHEMBL3405411 | 0.88 | CNR1 (0.46) | CNR1POLBMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |