Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 18/20 | 0.68 |
| ▸ | HTR2A | P28223 | 11/20 | 0.68 |
| ▸ | HTR1A | P08908 | 9/20 | 0.68 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | PGR | P06401 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402307 | 0.86 | DRD2 (0.74) | DRD2HTR2AHTR1ADRD3HTR3E | |
| SCHEMBL246427 | 0.85 | DRD2 (0.66) | DRD2HTR2AHTR1ADRD3HTR3E | |
| SCHEMBL3407475 | 0.84 | SLC6A2 (0.61) | DRD2HTR1ADRD3MEN1MAPT | |
| SCHEMBL13160190 | 0.83 | HTR1A (0.57) | DRD2HTR2AHTR1ADRD3MEN1 | |
| SCHEMBL28621606 | 0.83 | DRD2 (0.58) | DRD2HTR2AHTR1ADRD3HTR3E | |
| SCHEMBL14494782 | 0.83 | DRD2 (0.58) | DRD2HTR2AHTR1ADRD3DRD4 | |
| SCHEMBL182966 | 0.82 | DRD2 (0.57) | DRD2HTR2AHTR1ADRD3DRD1 | |
| SCHEMBL28490438 | 0.81 | DRD2 (0.66) | DRD2HTR2AHTR1ADRD3HTR3E | |
| SCHEMBL14494805 | 0.80 | DRD2 (0.56) | DRD2HTR2AHTR1ADRD3DRD4 | |
| SCHEMBL28485682 | 0.76 | DRD2 (0.72) | DRD2HTR2AHTR1ADRD3HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575185-B2 | Compositions, synthesis, and methods of utilizing quinazolinedione derivatives | REVIVA PHARMACEUTICALS, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| WO-2010099503-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING QUINAZOLINEDIONE DERIVATIVES | REVIVA PHARMACEUTICALS, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
| US-20100222359-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING QUINAZOLINEDIONE DERIVATIVES | REVIVA PHARMACEUTICALS, INC. | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222359-A1 | COMPOSITIONS, SYNTHESIS, AND METHODS OF UTILIZING QUINAZOLINEDIONE DERIVATIVES | GRIN2D, GRIK5, GRIK4 | DRD2 82/4885HTR2A 195/4885HTR1A 398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.