Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.57 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.47 |
| ▸ | GSTK1 | Q9Y2Q3 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 6/20 | 0.46 |
| ▸ | PPARD | Q03181 | 6/20 | 0.46 |
| ▸ | PPARA | Q07869 | 6/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propanol SCHEMBL14742011 | 0.82 | CHRNB2 (0.56) | CHRNB2CHRNB4CHRNA4TSHRFFAR4 | |
| SCHEMBL247201 | 0.82 | CHRNB2 (0.54) | CHRNB2CHRNB4CHRNA4KDM4CKDM4A | |
| Trimethylammonium SCHEMBL10593880 | 0.81 | KDM4C (0.62) | TSHRFFAR4FFAR1LMNANFKB1 | |
| SCHEMBL1131759 | 0.80 | TSHR (0.57) | TSHRFFAR4FFAR1LMNANFKB1 | |
| SCHEMBL9405636 | 0.78 | TSHR (0.60) | TSHRFFAR4FFAR1LMNANFKB1 | |
| SCHEMBL17866996 | 0.78 | ALDH1A1 (0.61) | TSHRFFAR4FFAR1LMNANFKB1 | |
| SCHEMBL399776 | 0.78 | KDM4C (0.63) | TSHRFFAR4FFAR1LMNANFKB1 | |
| SCHEMBL9405656 | 0.78 | TSHR (0.60) | TSHRFFAR4FFAR1LMNANFKB1 | |
| SCHEMBL19940379 | 0.78 | TSHR (0.60) | TSHRFFAR4FFAR1LMNANFKB1 | |
| Adipic Acid SCHEMBL18794878 | 0.78 | KDM4C (0.63) | TSHRFFAR4FFAR1LMNANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8501991-B2 | P53 activating compounds | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2013-08-06 | — | — | US | disclosed |
| EP-2099445-B1 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIV DUNDEE (GB) | 2010-11-17 | — | — | EP | disclosed |
| EP-2099445-A2 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | University Court of The University of Dundee (GB) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008029096-A2 | P53 ACTIVATING BENZOYL UREA AND BENZOYL THIOUREA COMPOUNDS | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2008-03-13 | — | — | WO | disclosed |