Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.67 |
| ▸ | RAB9A | P51151 | 11/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.50 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5452223 | 0.91 | TMPRSS2 (0.55) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL5469377 | 0.88 | POLB (0.55) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL1188325 | 0.86 | NPC1 (0.61) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL3405294 | 0.86 | RAB9A (0.63) | NPC1RAB9ACASP3SENP7TP53 | |
| SCHEMBL5458367 | 0.85 | RAB9A (0.69) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL8132666 | 0.83 | NPC1 (0.72) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL1188460 | 0.81 | NPC1 (0.52) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL1188034 | 0.81 | NPC1 (0.52) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL1188459 | 0.81 | NPC1 (0.52) | NPC1RAB9ACASP3SENP7MAPT | |
| SCHEMBL1188032 | 0.81 | NPC1 (0.52) | NPC1RAB9ACASP3SENP7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256105-B1 | NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-12-04 | — | — | EP | disclosed |
| EP-2256105-A1 | NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2010-12-01 | — | — | EP | disclosed |