Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.63 |
| ▸ | NPC1 | O15118 | 10/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TMPRSS2 | O15393 | 4/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.50 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.50 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.50 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.50 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5459990 | 0.87 | NPC1 (0.67) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3402909 | 0.86 | NPC1 (0.67) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5458367 | 0.84 | RAB9A (0.69) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14862974 | 0.84 | TMPRSS2 (0.61) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1188540 | 0.83 | ESR2 (0.62) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5469377 | 0.83 | POLB (0.55) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5452223 | 0.83 | TMPRSS2 (0.55) | RAB9ANPC1MEN1KMT2ATMPRSS2 | |
| SCHEMBL3409792 | 0.81 | KCNA1 (0.51) | RAB9ANPC1SMN1; SMN2TP53TMPRSS2 | |
| SCHEMBL3404203 | 0.80 | THRB (0.49) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL11903038 | 0.80 | TMPRSS2 (0.50) | RAB9ANPC1MEN1KMT2ATMPRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256105-B1 | NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-12-04 | — | — | EP | disclosed |
| EP-2256105-A1 | NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2010-12-01 | — | — | EP | disclosed |