Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143089 | 1.00 | GRIN2B (0.42) | GRIN2BADAM17NAAAFFAR1KDM4E | |
| SCHEMBL144742 | 0.91 | GRIN2B (0.42) | GRIN2BADAM17NAAAKDM4EALDH1A1 | |
| SCHEMBL16402964 | 0.84 | ALDH1A1 (0.34) | GRIN2BADAM17KDM4EALDH1A1CYP3A4 | |
| SCHEMBL145242 | 0.82 | GRIN2B (0.45) | GRIN2BADAM17NAAATSHR | |
| SCHEMBL142211 | 0.81 | GRIN2B (0.43) | GRIN2BADAM17NAAA | |
| SCHEMBL3400543 | 0.81 | GRIN2B (0.43) | GRIN2BADAM17NAAA | |
| SCHEMBL145119 | 0.80 | GRIN2B (0.43) | GRIN2BADAM17NAAA | |
| SCHEMBL141076 | 0.78 | GRIN2B (0.42) | GRIN2BADAM17NAAAKDM4EALDH1A1 | |
| SCHEMBL26695056 | 0.78 | NAAA (0.40) | GRIN2BNAAAFFAR1KDM4EALDH1A1 | |
| SCHEMBL26695170 | 0.78 | NAAA (0.40) | GRIN2BNAAAFFAR1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250171-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | Achaogen, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |