Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 18/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.38 |
| ▸ | RPTOR | Q8N122 | 11/20 | 0.38 |
| ▸ | MLST8 | Q9BVC4 | 11/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.38 |
| ▸ | RICTOR | Q6R327 | 7/20 | 0.38 |
| ▸ | MAPKAP1 | Q9BPZ7 | 7/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404771 | 0.81 | MTOR (0.40) | CYP3A4MAPK14MTORPIK3CAPIK3CD | |
| SCHEMBL3404768 | 0.81 | MTOR (0.40) | CYP3A4MAPK14MTORPIK3CAPIK3CD | |
| SCHEMBL3405879 | 0.80 | CTSK (0.53) | CTSSCTSKKCNH2 | |
| SCHEMBL25080335 | 0.71 | MTOR (0.42) | CYP3A4MAPK14MTORPIK3CARPTOR | |
| SCHEMBL31672763 | 0.71 | PDCD1 (0.46) | MTORPIK3CARPTORMLST8PIK3R1 | |
| SCHEMBL2708210 | 0.70 | MTOR (0.47) | MTORPIK3CARPTORMLST8PIK3R1 | |
| SCHEMBL2708205 | 0.70 | MTOR (0.47) | MTORPIK3CARPTORMLST8PIK3R1 | |
| SCHEMBL22759261 | 0.70 | MTOR (0.50) | MTORPIK3CARPTORMLST8PIK3R1 | |
| SCHEMBL22759089 | 0.70 | MTOR (0.50) | MTORPIK3CARPTORMLST8PIK3R1 | |
| SCHEMBL21029958 | 0.69 | MTOR (0.53) | MTORPIK3CARPTORMLST8PIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252296-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | Wyeth LLC (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009091788-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-07-23 | — | — | WO | disclosed |
| US-20090181963-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH (US) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181963-A1 | 3H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | MTOR, PIK3CA, PIK3CD | CYP3A4 1276/4885MAPK14 165/4885MTOR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.