Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 6/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL28485616 | 0.87 | KDM4E (0.45) | KDM4ENPC1HTTRAB9ABLM | |
| SCHEMBL16061135 | 0.81 | ALDH1A1 (0.47) | KDM4ENPC1HTTRAB9ABLM | |
| SCHEMBL23409095 | 0.73 | NUDT14 (0.64) | PIK3CDSRCEGFRABL1PIK3CB | |
| SCHEMBL22567087 | 0.72 | KHK (0.47) | ALDH1A1LMNAMAPTDHFR | |
| SCHEMBL17264219 | 0.71 | SRC (0.52) | KDM4ENPC1HTTRAB9ABLM | |
| SCHEMBL13790393 | 0.71 | NPC1 (1.00) | KDM4ENPC1HTTRAB9ABLM | |
| Hydrochloric Acid SCHEMBL29369186 | 0.71 | KHK (0.46) | ALDH1A1LMNAMAPTDHFR | |
| Hydrochloric Acid SCHEMBL22559675 | 0.71 | KHK (0.46) | ALDH1A1LMNAMAPTDHFR | |
| SCHEMBL6205168 | 0.71 | GSK3B (0.61) | NPC1HTTRAB9AHSD17B10PIK3CD | |
| SCHEMBL6207166 | 0.71 | GSK3B (0.66) | KDM4ENPC1RAB9ANPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254572-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | Massachusetts Eye & Ear Infirmary (US) | 2010-12-01 | — | — | EP | claimed |
| WO-2009100438-A2 | COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2009-08-13 | — | — | WO | claimed |