Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404918 | 0.89 | MAPT (0.50) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3401729 | 0.86 | RAB9A (0.54) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3402129 | 0.85 | HTR2C (0.43) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3402280 | 0.85 | CDC7 (0.44) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3401528 | 0.85 | PPARA (0.52) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL13071478 | 0.84 | CDC7 (0.44) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3404948 | 0.84 | SMN1; SMN2 (0.56) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3398655 | 0.84 | TRPM8 (0.47) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3400511 | 0.83 | NPC1 (0.43) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3405703 | 0.82 | MCHR1 (0.52) | NPC1HPGDALDH1A1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |