Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13071478 | 0.89 | CDC7 (0.44) | MAPTRAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL3401729 | 0.89 | RAB9A (0.54) | MAPTRAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL3403795 | 0.89 | NPC1 (0.47) | MAPTRAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL3402280 | 0.88 | CDC7 (0.44) | MAPTRAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL3401528 | 0.88 | PPARA (0.52) | MAPTRAB9ASMN1; SMN2HPGDTSHR | |
| SCHEMBL3398655 | 0.87 | TRPM8 (0.47) | MAPTRAB9ASMN1; SMN2HPGDTP53 | |
| SCHEMBL3404948 | 0.87 | SMN1; SMN2 (0.56) | MAPTRAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL3400511 | 0.86 | NPC1 (0.43) | MAPTRAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL3403051 | 0.85 | SMN1; SMN2 (0.43) | MAPTRAB9ASMN1; SMN2HPGDNPC1 | |
| SCHEMBL3405629 | 0.85 | CRHR1 (0.43) | MAPTRAB9ASMN1; SMN2HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |