Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.48 |
| ▸ | SMYD2 | Q9NRG4 | 8/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404913 | 0.97 | PPARD (0.53) | PPARDPPARACHRM4SMYD2ACP1 | |
| SCHEMBL3405687 | 0.93 | PPARD (0.54) | PPARDPPARACHRM4SMYD2ACP1 | |
| SCHEMBL3400860 | 0.92 | PPARD (0.54) | PPARDPPARACHRM4SMYD2ACP1 | |
| SCHEMBL3403787 | 0.87 | SMYD2 (0.50) | PPARDPPARACHRM4SMYD2DRD2 | |
| SCHEMBL3405123 | 0.85 | HTR3A (0.55) | SMYD2DRD2HTR2AHTR1ADRD3 | |
| SCHEMBL3400465 | 0.85 | SMYD2 (0.47) | CHRM4SMYD2DRD2HTR2AHTR1A | |
| SCHEMBL3401247 | 0.84 | PPARD (0.48) | PPARDPPARACHRM4LMNAMAPT | |
| SCHEMBL3399440 | 0.84 | CHRM4 (0.62) | PPARDPPARACHRM4GAADRD3 | |
| SCHEMBL3402982 | 0.83 | SMYD2 (0.53) | PPARDPPARACHRM4SMYD2ACP1 | |
| SCHEMBL3403830 | 0.83 | HTR3A (0.47) | SMYD2DRD2HTR2AHTR1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |