Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405687 | 0.99 | PPARD (0.54) | PPARDPPARACHRM4HTR2CPARP1 | |
| SCHEMBL3404913 | 0.93 | PPARD (0.53) | PPARDPPARACHRM4HTR2CACP1 | |
| SCHEMBL3404056 | 0.92 | PPARD (0.52) | PPARDPPARACHRM4ACP1SMYD2 | |
| SCHEMBL3401416 | 0.86 | NPC1 (0.53) | PPARDPPARACHRM4HTR2CPARP1 | |
| SCHEMBL3402762 | 0.85 | NPC1 (0.53) | PPARDPPARACHRM4HTR2CPARP1 | |
| SCHEMBL3401847 | 0.84 | HTR2C (0.45) | CHRM4HTR2CPARP1POLBKDM4E | |
| SCHEMBL3403561 | 0.83 | WNT1 (0.52) | CHRM4HTR2CPARP1POLBTSHR | |
| SCHEMBL3403455 | 0.83 | PARP1 (0.46) | CHRM4HTR2CPARP1POLBKDM4E | |
| SCHEMBL3405526 | 0.83 | PPARD (0.53) | PPARDPPARACHRM4HTR2CNPC1 | |
| SCHEMBL3405595 | 0.82 | PDE2A (0.47) | PPARDPPARACHRM4HTR2CPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |