Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD2 | Q9NRG4 | 8/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403455 | 0.93 | PARP1 (0.46) | SMYD2GAACHRM4NPC1HPGD | |
| SCHEMBL3401847 | 0.92 | HTR2C (0.45) | SMYD2GAACHRM4NPC1HPGD | |
| SCHEMBL3403787 | 0.87 | SMYD2 (0.50) | SMYD2GAADRD3DRD2CHRM4 | |
| SCHEMBL3403830 | 0.85 | HTR3A (0.47) | SMYD2GAADRD3DRD2L3MBTL1 | |
| SCHEMBL3405123 | 0.85 | HTR3A (0.55) | SMYD2DRD3DRD2HTR2CHTR1A | |
| SCHEMBL3404056 | 0.85 | PPARD (0.52) | SMYD2GAADRD3DRD2CHRM4 | |
| SCHEMBL3402446 | 0.84 | RAB9A (0.47) | NPC1HPGDL3MBTL1 | |
| SCHEMBL3402982 | 0.83 | SMYD2 (0.53) | SMYD2GAACHRM4NPC1 | |
| SCHEMBL3396859 | 0.83 | DRD2 (0.51) | SMYD2GAADRD3DRD2HTR2C | |
| SCHEMBL3404866 | 0.83 | MCHR1 (0.46) | SMYD2GAADRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |