Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 2/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MELK | Q14680 | 8/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404543 | 0.84 | GRIA2 (0.42) | GRIA4GRIA2ALDH1A1MAPK1GAA | |
| SCHEMBL6796039 | 0.82 | ALDH1A1 (0.58) | GRIA4GRIA2ALDH1A1LMNAMAPK1 | |
| SCHEMBL16690053 | 0.81 | GRIA2 (0.40) | GRIA4GRIA2ALDH1A1GAAMAPT | |
| SCHEMBL5731532 | 0.81 | GRIA4 (0.53) | GRIA4GRIA2ALDH1A1LMNAMAPK1 | |
| SCHEMBL3206052 | 0.78 | GRIA4 (0.61) | GRIA4GRIA2ALDH1A1LMNAMAPK1 | |
| SCHEMBL4422079 | 0.78 | GRIA4 (0.51) | GRIA4GRIA2ALDH1A1LMNAMAPK1 | |
| SCHEMBL9097378 | 0.76 | MELK (0.41) | GRIA4ALDH1A1LMNAMAPK1GAA | |
| SCHEMBL6795094 | 0.73 | MEN1 (0.44) | GRIA4GRIA2ALDH1A1LMNAMAPK1 | |
| SCHEMBL1552287 | 0.73 | GRIA2 (0.43) | GRIA4GRIA2ALDH1A1MAPK1GAA | |
| SCHEMBL7054378 | 0.72 | GRIA2 (0.39) | GRIA4GRIA2ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250160-A1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | Millennium Pharmaceuticals, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009094224-A1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-30 | — | — | WO | disclosed |