Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 7/20 | 0.51 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.51 |
| ▸ | FNTA | P49354 | 12/20 | 0.38 |
| ▸ | FNTB | P49356 | 12/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731532 | 0.78 | GRIA4 (0.53) | GRIA4GRIA2FNTAFNTBALDH1A1 | |
| SCHEMBL3404253 | 0.78 | GRIA4 (0.53) | GRIA4GRIA2ALDH1A1LMNAMAPK1 | |
| SCHEMBL4412987 | 0.77 | GRIA4 (0.55) | GRIA4GRIA2FNTAFNTBALDH1A1 | |
| SCHEMBL3206052 | 0.76 | GRIA4 (0.61) | GRIA4GRIA2FNTAFNTBALDH1A1 | |
| SCHEMBL4418655 | 0.72 | FNTA (0.34) | GRIA4GRIA2FNTAFNTB | |
| SCHEMBL3404543 | 0.70 | GRIA2 (0.42) | GRIA4GRIA2ALDH1A1MAPK1KMT2A | |
| SCHEMBL3126306 | 0.68 | GRIA4 (1.00) | GRIA4GRIA2FNTAFNTBKMT2A | |
| SCHEMBL4417287 | 0.68 | PIK3CA (0.58) | GRIA4GRIA2ALDH1A1 | |
| SCHEMBL1552287 | 0.68 | GRIA2 (0.43) | GRIA4GRIA2ALDH1A1MAPK1 | |
| SCHEMBL6796039 | 0.65 | ALDH1A1 (0.58) | GRIA4GRIA2ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325925-A1 | Thiophenes and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325925-A1 | Thiophenes and uses thereof | PIK3CA, JAK2, MTOR | GRIA4 2350/4885GRIA2 2570/4885FNTA 3475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.