Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 11/20 | 0.61 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 5/20 | 0.31 |
| ▸ | FNTB | P49356 | 5/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731532 | 0.78 | GRIA4 (0.53) | GRIA4GRIA2LMNAALDH1A1MAPK1 | |
| SCHEMBL3404253 | 0.78 | GRIA4 (0.53) | GRIA4GRIA2LMNAALDH1A1MAPK1 | |
| SCHEMBL3126306 | 0.76 | GRIA4 (1.00) | GRIA4GRIA2FNTAFNTBKMT2A | |
| SCHEMBL4422079 | 0.76 | GRIA4 (0.51) | GRIA4GRIA2LMNAALDH1A1MAPK1 | |
| SCHEMBL1552287 | 0.68 | GRIA2 (0.43) | GRIA4GRIA2ALDH1A1MAPK1 | |
| SCHEMBL3404543 | 0.67 | GRIA2 (0.42) | GRIA4GRIA2ALDH1A1MAPK1KMT2A | |
| SCHEMBL3131405 | 0.66 | GRIA4 (0.79) | GRIA4GRIA2MAPK1FNTAFNTB | |
| SCHEMBL6796039 | 0.65 | ALDH1A1 (0.58) | GRIA4GRIA2LMNAALDH1A1MAPK1 | |
| SCHEMBL3135115 | 0.61 | GRIA4 (0.49) | GRIA4GRIA2ALDH1A1MAPK1KMT2A | |
| SCHEMBL3816299 | 0.60 | ALDH1A1 (0.44) | GRIA4GRIA2LMNAALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786048-B2 | Condensed heterocyclic pyrazole derivatives as kinase inhibitors | PFIZER ITALIA S.R.L. (IT) | 2010-08-31 | — | — | US | disclosed |
| US-20090233813-A1 | Condensed Heterocyclic Pyrazole Derivatives as Kinase Inhibitors | PFIZER ITALIA S.R.L. (IT) | 2009-09-17 | — | — | US | disclosed |