SCHEMBL3404594

SCHEMBL3404594

Brc1ccc(Br)c(C2CC2)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.39
TLR9 Q9NR96 1/20 0.39
PTGDR Q13258 1/20 0.39
PTGDR2 Q9Y5Y4 1/20 0.39
NOS3 P29474 1/20 0.38
NOS1 P29475 1/20 0.38
NOS2 P35228 1/20 0.38
ALOX15 P16050 1/20 0.36
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
HTR2B P41595 1/20 0.35
ALDH1A1 P00352 2/20 0.34
MAPK1 P28482 2/20 0.34
S100A4 P26447 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
KDM1A O60341 2/20 0.34
KDM1B Q8NB78 1/20 0.34
SLC6A4 P31645 2/20 0.34
CYP1A2 P05177 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11891807 0.91 PTGDR (0.44) HSP90AA1TLR9PTGDRPTGDR2NOS3
SCHEMBL28899720 0.89 PTGDR (0.50) HSP90AA1TLR9PTGDRPTGDR2NOS3
SCHEMBL16905177 0.83 PTGDR (0.40) PTGDRPTGDR2NOS3NOS1NOS2
SCHEMBL18769998 0.77 OPRL1 (0.38) PTGDRPTGDR2NOS3NOS1NOS2
SCHEMBL16962649 0.77 CHRNB2 (0.41) PTGDR2NOS3NOS1NOS2HTR2A
SCHEMBL23857836 0.77 HTR2C (0.38) PTGDRPTGDR2NOS3NOS1NOS2
SCHEMBL16291407 0.77 TAAR1 (0.42) PTGDRPTGDR2NOS3NOS1NOS2
SCHEMBL931388 0.77 ALOX15 (0.48) HSP90AA1PTGDRPTGDR2ALOX15HTR2A
SCHEMBL31586961 0.77 NOS3 (0.43) PTGDRPTGDR2NOS3NOS1NOS2
SCHEMBL16962647 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2260032-A2 FUNGICIDAL HETERCYCLIC COMPOUNDS E. I. du Pont de Nemours and Company (US) 2010-12-15 EP disclosed
WO-2009094445-A2 FUNGICIDAL HETERCYCLIC COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2009-07-30 WO disclosed