SCHEMBL3404773

CC(C)c1cccc(C(C)C)c1NC(=O)N(CC1(SCc2ccccc2)CCCCC1)N(CC1(S(=O)(=O)c2ccccc2)Cc2ccccc2C1)C(=O)Nc1c(C(C)C)cccc1C(C)C

nearest known ligand 0.40

Predicted protein targets (top 5)

	gene	UniProt	supporting neighbours	confidence
▸	SOAT2	O75908	2/20	0.36

▸	SOAT1	P35610	2/20	0.36

▸	ACAT1	P24752	1/20	0.36

▸	UBE2M	P61081	1/20	0.34

▸	DCUN1D1	Q96GG9	1/20	0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL3404765	0.74	SOAT1 (0.53)	SOAT2SOAT1ACAT1
SCHEMBL3410909	0.74	NLRP3 (0.46)	—
SCHEMBL3406757	0.73	SOAT1 (0.51)	SOAT2SOAT1ACAT1
SCHEMBL3404851	0.70	NLRP3 (0.41)	SOAT2SOAT1ACAT1
SCHEMBL3408628	0.70	SOAT1 (0.54)	SOAT2SOAT1ACAT1
SCHEMBL13083300	0.67	SOAT1 (0.44)	SOAT2SOAT1ACAT1
SCHEMBL3410552	0.64	SOAT1 (0.53)	SOAT2SOAT1ACAT1
SCHEMBL9765050	0.64	SOAT1 (0.51)	SOAT2SOAT1ACAT1UBE2MDCUN1D1
SCHEMBL3407860	0.63	NLRP3 (0.59)	SOAT2SOAT1ACAT1
SCHEMBL14236583	0.62	SOAT1 (0.54)	SOAT2SOAT1ACAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2200979-A1	NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM	Galderma Research & Development (FR)	2010-06-30	—	—	EP	claimed
WO-2009030752-A1	NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM	GALDERMA RESEARCH & DEVELOPMENT (FR)	2009-03-12	—	—	WO	claimed