Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 7/20 | 0.39 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.37 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409749 | 0.96 | IMPDH2 (0.42) | IMPDH2KCNH2ABCB1ABCC1ABCG2 | |
| SCHEMBL3410560 | 0.90 | NPC1 (0.37) | IMPDH2KCNH2ABCG2NPC1RAB9A | |
| SCHEMBL3406095 | 0.87 | CYP3A4 (0.44) | IMPDH2KCNH2ABCB1ABCC1ABCG2 | |
| SCHEMBL3406878 | 0.85 | SYK (0.50) | — | |
| SCHEMBL3412646 | 0.84 | SYK (0.46) | PLK1MAPK1AURKAKDRAURKB | |
| SCHEMBL3407100 | 0.84 | MAPT (0.48) | PTGS2MAPTLMNAMAPK1 | |
| SCHEMBL3410260 | 0.83 | NPC1 (0.53) | IMPDH2KCNH2ABCG2NPC1RAB9A | |
| SCHEMBL3406812 | 0.83 | IMPDH2 (0.39) | IMPDH2PTGS2ULK1ULK2PSEN1 | |
| SCHEMBL3406884 | 0.82 | TLR8 (0.56) | IMPDH2MAPTLMNAMAPK1 | |
| SCHEMBL3408862 | 0.82 | NPC1 (0.43) | IMPDH2KCNH2ABCG2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |