Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409722 | 0.90 | PIK3CA (0.41) | MAPTSMN1; SMN2LMNAHTTPTGS2 | |
| SCHEMBL3406378 | 0.88 | PTGS2 (0.42) | MAPTSMN1; SMN2LMNAPTGS2TP53 | |
| SCHEMBL3409749 | 0.87 | IMPDH2 (0.42) | MAPTLMNAPTGS2MAPK1 | |
| SCHEMBL3412354 | 0.85 | PTGS2 (0.39) | MAPTSMN1; SMN2LMNAPTGS2TP53 | |
| SCHEMBL3412057 | 0.84 | MAPT (0.42) | MAPTSMN1; SMN2LMNAPTGS2TP53 | |
| SCHEMBL3407305 | 0.84 | PIK3CA (0.61) | JAK2EGFRCDK2PIK3CAPIK3CB | |
| SCHEMBL3405216 | 0.84 | IMPDH2 (0.39) | MAPTLMNAPTGS2MAPK1 | |
| SCHEMBL3412730 | 0.83 | PIK3CA (0.40) | MAPTLMNATP53JAK2EGFR | |
| SCHEMBL3406812 | 0.83 | IMPDH2 (0.39) | MAPTLMNAPTGS2KDM4EALDH1A1 | |
| SCHEMBL3406884 | 0.82 | TLR8 (0.56) | MAPTSMN1; SMN2LMNATP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |