Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.41 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15535962 | 0.87 | SLC6A2 (0.57) | KDM4ESLC6A2SLC6A4SLC6A3FPR2 | |
| SCHEMBL2519453 | 0.86 | MEN1 (0.47) | KDM4ERPS6KB1LMNARAB9AALDH1A1 | |
| SCHEMBL15537475 | 0.81 | SLC6A4 (0.52) | SLC6A2SLC6A4SLC6A3FPR2PROKR1 | |
| SCHEMBL2523912 | 0.79 | SLC6A4 (0.53) | RPS6KB1SLC6A2SLC6A4SLC6A3CYP2C19 | |
| SCHEMBL2523911 | 0.79 | SLC6A4 (0.53) | RPS6KB1SLC6A2SLC6A4SLC6A3CYP2C19 | |
| SCHEMBL2523957 | 0.79 | SLC6A4 (0.53) | RPS6KB1SLC6A2SLC6A4SLC6A3CYP2C19 | |
| SCHEMBL15536002 | 0.73 | FPR2 (0.47) | KDM4ERPS6KB1FPR2PROKR1OPRD1 | |
| SCHEMBL15536845 | 0.72 | SLC6A2 (0.51) | KDM4ESLC6A2SLC6A4SLC6A3FPR2 | |
| SCHEMBL2517428 | 0.72 | AKT1 (0.56) | RPS6KB1 | |
| SCHEMBL2517506 | 0.72 | AKT1 (0.56) | RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250155-A1 | 5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009089462-A1 | 5H-CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |