Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.40 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406077 | 0.90 | PRMT5 (0.43) | PRMT5EGFRFGFR1KDRUBE2N | |
| SCHEMBL3406384 | 0.90 | PRMT5 (0.39) | PRMT5EGFRFGFR1KDRUBE2N | |
| SCHEMBL979310 | 0.88 | EGFR (0.39) | EGFRFGFR1KDRKMT2AMEN1 | |
| SCHEMBL3408673 | 0.88 | DRD2 (0.40) | EGFRFGFR1KDRLMNAHSD17B10 | |
| SCHEMBL3408729 | 0.87 | EGFR (0.40) | PRMT5EGFRFGFR1KDRKMT2A | |
| SCHEMBL977201 | 0.87 | CCR2 (0.40) | EGFRFGFR1KDRKMT2AMEN1 | |
| SCHEMBL3406222 | 0.87 | SCN9A (0.47) | EGFRFGFR1KDRGAAKMT2A | |
| SCHEMBL3401769 | 0.87 | EGFR (0.41) | EGFRFGFR1KDRLMNAMAP3K5 | |
| Hydrochloric Acid SCHEMBL6527164 | 0.87 | DRD2 (0.40) | EGFRFGFR1KDRLMNAHSD17B10 | |
| SCHEMBL975803 | 0.87 | EGFR (0.39) | PRMT5EGFRFGFR1KDRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254862-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | Sanofi-Aventis (FR) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009118473-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2009-10-01 | — | — | WO | disclosed |