Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6527164 | 0.99 | DRD2 (0.40) | DRD2DRD3HSD17B10EGFRFGFR1 | |
| SCHEMBL977614 | 0.90 | DRD2 (0.39) | DRD2DRD3EGFRFGFR1KDR | |
| SCHEMBL3406222 | 0.90 | SCN9A (0.47) | DRD2DRD3EGFRFGFR1KDR | |
| SCHEMBL979310 | 0.89 | EGFR (0.39) | DRD2DRD3EGFRFGFR1KDR | |
| SCHEMBL3406077 | 0.89 | PRMT5 (0.43) | DRD2DRD3EGFRFGFR1KDR | |
| SCHEMBL975803 | 0.88 | EGFR (0.39) | DRD2DRD3EGFRFGFR1KDR | |
| SCHEMBL3405536 | 0.88 | PRMT5 (0.41) | DRD2DRD3HSD17B10EGFRFGFR1 | |
| SCHEMBL3427255 | 0.87 | EGFR (0.39) | EGFRFGFR1KDRCNR1LMNA | |
| SCHEMBL3407500 | 0.87 | EGFR (0.37) | DRD2DRD3EGFRFGFR1KDR | |
| SCHEMBL3408729 | 0.87 | EGFR (0.40) | DRD2DRD3EGFRFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254862-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | Sanofi-Aventis (FR) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009118473-A2 | AZETIDINE-DERIVED COMPOUNDS, PREPARATION METHOD THEREFOR AND THERAPEUTIC USE OF SAME | SANOFI-AVENTIS (FR) | 2009-10-01 | — | — | WO | disclosed |