Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NMBR | P28336 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405365 | 0.94 | PKM (0.36) | PKMPOLBMETAP2METAP1EPHX1 | |
| SCHEMBL3406348 | 0.79 | PKM (0.39) | PKMPOLBMETAP2METAP1LMNA | |
| SCHEMBL3410558 | 0.78 | NMBR (0.48) | LMNANMBR | |
| SCHEMBL3412557 | 0.70 | NLRP3 (0.46) | EPHX1NMBREPHX2 | |
| SCHEMBL11424795 | 0.66 | TAS1R3 (0.42) | METAP2METAP1NMBREPHX2 | |
| SCHEMBL3414059 | 0.65 | NMBR (0.47) | LMNANMBRALDH1A1 | |
| SCHEMBL11423757 | 0.65 | PKM (0.49) | PKMPOLBEPHX1LMNAKDM4E | |
| SCHEMBL11417441 | 0.65 | PKM (0.49) | PKMPOLBEPHX1LMNAKDM4E | |
| SCHEMBL3414001 | 0.64 | NMBR (0.45) | LMNANMBRALDH1A1 | |
| SCHEMBL1400577 | 0.64 | NPSR1 (0.50) | POLBLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200979-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009030752-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-12 | — | — | WO | disclosed |