Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16984656 | 0.84 | TAS1R3 (0.41) | SMN1; SMN2ALDH1A1KMT2AHPGD | |
| SCHEMBL3406445 | 0.78 | ERCC5 (0.46) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL2475812 | 0.75 | F2R (0.43) | SMN1; SMN2ALDH1A1L3MBTL1LMNATDP1 | |
| SCHEMBL116339 | 0.74 | MAPK1 (0.67) | SMN1; SMN2HDAC1ALDH1A1TRPA1MAPK1 | |
| SCHEMBL7931239 | 0.72 | AKR1C3 (0.52) | SMN1; SMN2ALDH1A1L3MBTL1MAPTLMNA | |
| Ethylene SCHEMBL11817466 | 0.71 | MAPK1 (0.61) | SMN1; SMN2HDAC1ALDH1A1TRPA1MAPK1 | |
| SCHEMBL2837238 | 0.71 | ERCC5 (0.58) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL15979727 | 0.70 | NR4A2 (0.59) | SMN1; SMN2HDAC1ALDH1A1TRPA1MAPK1 | |
| SCHEMBL5057138 | 0.70 | PTPN1 (0.50) | ALDH1A1GSK3BKMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL30461901 | 0.69 | ERCC5 (0.56) | SMN1; SMN2ALDH1A1MAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214650-A2 | BUPROPION HYDROBROMIDE AND THERAPEUTIC APPLICATIONS | Biovail Laboratories International SRL (BB) | 2010-08-11 | — | — | EP | disclosed |
| WO-2010015692-A2 | BUPROPION HYDROBROMIDE POLYMORPHS | BIOVAIL LABORATORIES INTERNATIONAL SRL (BB) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009056550-A2 | BUPROPION HYDROBROMIDE AND THERAPEUTIC APPLICATIONS | BIOVAIL LABORATORIES INTERNATIONAL SRL (BB) | 2009-05-07 | — | — | WO | disclosed |