Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16984656 | 0.87 | TAS1R3 (0.41) | ERCC5FEN1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL116338 | 0.83 | ERCC5 (0.61) | ERCC5FEN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3406437 | 0.78 | SMN1; SMN2 (0.40) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL28016993 | 0.77 | ERCC5 (0.51) | ERCC5FEN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8020335 | 0.74 | SLC6A2 (0.50) | ERCC5FEN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2475812 | 0.74 | F2R (0.43) | ERCC5FEN1SMN1; SMN2MEN1KMT2A | |
| Tert-Butylamine SCHEMBL3326036 | 0.74 | PARP1 (0.50) | ERCC5FEN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL18184926 | 0.72 | ERCC5 (0.56) | ERCC5FEN1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5057138 | 0.72 | PTPN1 (0.50) | ERCC5FEN1MEN1KMT2AALDH1A1 | |
| SCHEMBL15979728 | 0.72 | ERCC5 (0.51) | ERCC5FEN1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214650-A2 | BUPROPION HYDROBROMIDE AND THERAPEUTIC APPLICATIONS | Biovail Laboratories International SRL (BB) | 2010-08-11 | — | — | EP | disclosed |
| WO-2010015692-A2 | BUPROPION HYDROBROMIDE POLYMORPHS | BIOVAIL LABORATORIES INTERNATIONAL SRL (BB) | 2010-02-11 | — | — | WO | disclosed |
| WO-2009056550-A2 | BUPROPION HYDROBROMIDE AND THERAPEUTIC APPLICATIONS | BIOVAIL LABORATORIES INTERNATIONAL SRL (BB) | 2009-05-07 | — | — | WO | disclosed |