Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 6/20 | 0.34 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3059903 | 0.87 | PDE10A (0.35) | PDE10AENPP2TP53MAPTLMNA | |
| SCHEMBL3068576 | 0.83 | TP53 (0.38) | PDE10ANPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL3060632 | 0.82 | TP53 (0.43) | PDE10ANPC1PKMRAB9ASMN1; SMN2 | |
| SCHEMBL3070806 | 0.80 | ENPP2 (0.36) | NPC1PKMRAB9ASMN1; SMN2ENPP2 | |
| SCHEMBL3067932 | 0.80 | TP53 (0.44) | SMN1; SMN2TP53MAPTLMNAPOLB | |
| SCHEMBL3055020 | 0.80 | AGTR2 (0.37) | PDE10ARAB9AENPP2TP53MEN1 | |
| SCHEMBL3064818 | 0.79 | ENPP2 (0.35) | NPC1PKMRAB9ASMN1; SMN2ENPP2 | |
| SCHEMBL3060545 | 0.74 | PDE10A (0.33) | PDE10AMEN1KMT2AADORA2AADORA1 | |
| SCHEMBL13089466 | 0.74 | GRM2 (0.34) | PDE10ATP53 | |
| SCHEMBL3062897 | 0.73 | PKM (0.36) | PDE10APKMLMNAADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368342-B3 | BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | NEUROGEN CORP (US) | 2010-12-01 | — | — | EP | disclosed |