Sugi Predict

Sugi Predict / Compounds / SCHEMBL3406602

SCHEMBL3406602

SCHEMBL3406602

O=C(Cc1cccc2ccccc12)NC1CC2(CCC2)Oc2cccc(O)c21

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ SIGMAR1 Q99720 1/20 0.42
▸ MEN1 O00255 3/20 0.39
▸ KMT2A Q03164 3/20 0.39
▸ TRPV1 Q8NER1 2/20 0.39
▸ ATM Q13315 1/20 0.39
▸ CCNA2 P20248 1/20 0.39
▸ CDK2 P24941 1/20 0.39
▸ CCNA1 P78396 1/20 0.39
▸ MAPT P10636 2/20 0.38
▸ EPHX1 P07099 1/20 0.38
▸ HPGD P15428 2/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ SMN1; SMN2 Q16637 2/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ TDP1 Q9NUW8 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ PTGER4 P35408 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3429908 0.91 TRPV1 (0.47) SIGMAR1MEN1KMT2ATRPV1ATM
SCHEMBL3431254 0.83 SIGMAR1 (0.43) SIGMAR1MEN1KMT2ATRPV1ATM
SCHEMBL3803774 0.82 TRPV3 (0.47) SIGMAR1MEN1KMT2ATRPV1CCNA2
SCHEMBL13021227 0.82 TRPV1 (0.53) KMT2ATRPV1
SCHEMBL3799654 0.82 TRPV3 (0.47) SIGMAR1MEN1KMT2ATRPV1CCNA2
SCHEMBL3427065 0.82 TRPV3 (0.47) SIGMAR1MEN1KMT2ATRPV1CCNA2
SCHEMBL3401030 0.82 MEN1 (0.46) SIGMAR1MEN1KMT2ATRPV1ATM
SCHEMBL13770903 0.82 SIGMAR1 (0.41) SIGMAR1MEN1KMT2ATRPV1ATM
SCHEMBL3798851 0.80 CNR1 (0.43) SIGMAR1MEN1KMT2ATRPV1ATM
SCHEMBL3800827 0.80 CNR1 (0.43) SIGMAR1MEN1KMT2ATRPV1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8487121-B2 Chromane derivatives as TRPV3 modulators GLENMARK PHARMACEUTICALS S.A. (CH) 2013-07-16 — — US claimed
US-20100311778-A1 CHROMANE DERIVATIVES AS TRPV3 MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2010-12-09 — — US claimed
US-8487121-B2 Chromane derivatives as TRPV3 modulators GLENMARK PHARMACEUTICALS S.A. (CH) 2013-07-16 — — US disclosed
US-8487121-B2 Chromane derivatives as TRPV3 modulators GLENMARK PHARMACEUTICALS S.A. (CH) 2013-07-16 — — US disclosed
US-8487121-B2 Chromane derivatives as TRPV3 modulators GLENMARK PHARMACEUTICALS S.A. (CH) 2013-07-16 — — US disclosed
US-20100311778-A1 CHROMANE DERIVATIVES AS TRPV3 MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2010-12-09 — — US disclosed
US-20100311778-A1 CHROMANE DERIVATIVES AS TRPV3 MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2010-12-09 — — US disclosed
US-20100311778-A1 CHROMANE DERIVATIVES AS TRPV3 MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2010-12-09 — — US disclosed
EP-2254879-A2 CHROMANE DERIVATIVES AS TRPV3 MODULATORS Glenmark Pharmaceuticals S.A. (CH) 2010-12-01 — — EP disclosed
WO-2009084034-A2 CHROMANE DERIVATIVES AS TRPV3 MODULATORS GLENMARK PHARMACEUTICALS, S. A. (CH) 2009-07-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100311778-A1 CHROMANE DERIVATIVES AS TRPV3 MODULATORS TRPV3, TRPV2, TRPV1 SIGMAR1 918/4885MEN1 4608/4885KMT2A 3898/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.