Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 7/20 | 0.81 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.81 |
| ▸ | PGR | P06401 | 6/20 | 0.81 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.81 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.81 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.81 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.81 |
| ▸ | AR | P10275 | 3/20 | 0.74 |
| ▸ | F2 | P00734 | 1/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | IL6 | P05231 | 1/20 | 0.55 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.55 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.55 |
| ▸ | GLUL | P15104 | 1/20 | 0.55 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406702 | 1.00 | CYP3A4 (0.81) | CYP3A4HIF1APGRNR3C1HSD17B10 | |
| SCHEMBL11691394 | 0.92 | CYP3A4 (0.78) | CYP3A4HIF1APGRNR3C1HSD17B10 | |
| SCHEMBL11691405 | 0.92 | CYP3A4 (0.78) | CYP3A4HIF1APGRNR3C1HSD17B10 | |
| SCHEMBL13069748 | 0.92 | HIF1A (0.81) | CYP3A4HIF1APGRNR3C1HSD17B10 | |
| SCHEMBL11271565 | 0.92 | HIF1A (0.81) | CYP3A4HIF1APGRNR3C1HSD17B10 | |
| SCHEMBL3397738 | 0.92 | HIF1A (0.81) | CYP3A4HIF1APGRNR3C1HSD17B10 | |
| SCHEMBL3397741 | 0.92 | HIF1A (0.81) | CYP3A4HIF1APGRNR3C1HSD17B10 | |
| SCHEMBL21145516 | 0.90 | CYP3A4 (0.78) | CYP3A4HIF1APGRNR3C1HSD17B10 | |
| Methylprednisolone SCHEMBL5085 | 0.89 | HIF1A (1.00) | CYP3A4HIF1APGRNR3C1HSD17B10 | |
| Methylprednisolone SCHEMBL21145528 | 0.89 | HIF1A (1.00) | CYP3A4HIF1APGRNR3C1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130237507-A1 | Novel Amide Compounds | ASTRAZENECA AB INTELLECTUAL PROPERTY (GB) | 2013-09-12 | — | — | US | disclosed |
| US-20100256104-A1 | NOVEL AMIDE COMPOUNDS | ASTRAZENECA R&D (SE) | 2010-10-07 | — | — | US | disclosed |
| EP-0902789-B1 | ANDROSTENE DERIVATIVES | SOFT DRUGS INC (US) | 2002-01-23 | — | — | EP | disclosed |
| US-5646136-A | ADMINISTERING STEROID HAVING ANGIOSTATIC ACTIVITY TO A PATIENT | DUKE UNIVERSITY (US) | 1997-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100256104-A1 | NOVEL AMIDE COMPOUNDS | H1-4, H1-3, H1-5 | CYP3A4 213/4885HIF1A 1464/4885PGR 454/4885 |
| US-20130237507-A1 | Novel Amide Compounds | H1-4, H1-3, H1-5 | CYP3A4 181/4885HIF1A 1279/4885PGR 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.