Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | CCND1 | P24385 | 2/20 | 0.39 |
| ▸ | CCND2 | P30279 | 2/20 | 0.39 |
| ▸ | CCND3 | P30281 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3412596 | 0.92 | PLK1 (0.42) | BRD4IMPDH2PAK1PLK1MAPT | |
| SCHEMBL3410218 | 0.90 | IMPDH2 (0.41) | BRD4IMPDH2PAK1PLK1MAPT | |
| SCHEMBL3412246 | 0.84 | SYK (0.42) | BRD4IMPDH2PAK1MAPTNPC1 | |
| SCHEMBL3410488 | 0.82 | BRD4 (0.40) | BRD4IMPDH2PLK1JAK2JAK1 | |
| SCHEMBL3410480 | 0.82 | MEN1 (0.48) | IMPDH2MAPTNPC1MEN1KMT2A | |
| SCHEMBL3410539 | 0.81 | MAPT (0.43) | BRD4IMPDH2PAK1MAPTNPC1 | |
| SCHEMBL3411191 | 0.81 | BRD4 (0.45) | BRD4IMPDH2PAK1PLK1MAPT | |
| SCHEMBL3409944 | 0.81 | MAPT (0.42) | BRD4IMPDH2PAK1MAPTNPC1 | |
| SCHEMBL3411147 | 0.80 | BRD4 (0.46) | BRD4PAK1PLK1MAPTNPC1 | |
| SCHEMBL3406529 | 0.80 | MEN1 (0.41) | BRD4IMPDH2PAK1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |