Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 6/20 | 0.40 |
| ▸ | JAK1 | P23458 | 6/20 | 0.40 |
| ▸ | JAK3 | P52333 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | PLK1 | P53350 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.39 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405288 | 0.86 | KDR (0.41) | BRD4JAK2JAK1JAK3CYP3A4 | |
| SCHEMBL3410260 | 0.83 | NPC1 (0.53) | BRD4IMPDH2 | |
| SCHEMBL3408826 | 0.83 | CYP17A1 (0.42) | BRD4JAK2JAK1JAK3CYP3A4 | |
| SCHEMBL3406073 | 0.83 | PIK3CA (0.41) | BRD4PLK1IMPDH2PDGFRBPDGFRA | |
| SCHEMBL3412646 | 0.83 | SYK (0.46) | BRD4PLK1KDR | |
| SCHEMBL3407097 | 0.82 | BRD4 (0.41) | BRD4JAK2JAK1PLK1TYK2 | |
| SCHEMBL3410455 | 0.82 | MEN1 (0.42) | CYP3A4PLK1CYP1A2IMPDH2ULK1 | |
| SCHEMBL3406191 | 0.82 | IMPDH2 (0.45) | PLK1CYP1A2IMPDH2KDR | |
| SCHEMBL3410226 | 0.82 | PLK1 (0.47) | JAK2JAK1JAK3CYP3A4PLK1 | |
| SCHEMBL3410316 | 0.81 | IMPDH2 (0.44) | IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |