Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3410539 | 0.85 | MAPT (0.43) | MAPTNPC1BRD4NPSR1IMPDH2 | |
| SCHEMBL3412922 | 0.83 | IMPDH2 (0.39) | IMPDH2MAPK8MAPK9 | |
| SCHEMBL4101444 | 0.81 | PSEN1 (0.48) | MAPTNPC1BRD4 | |
| SCHEMBL3407097 | 0.81 | BRD4 (0.41) | MAPTNPC1BRD4IMPDH2PAK1 | |
| SCHEMBL3411191 | 0.80 | BRD4 (0.45) | MAPTNPC1BRD4IMPDH2PAK1 | |
| SCHEMBL3412596 | 0.80 | PLK1 (0.42) | MAPTNPC1BRD4IMPDH2PAK1 | |
| SCHEMBL3411147 | 0.79 | BRD4 (0.46) | MAPTNPC1BRD4PAK1CDK2 | |
| SCHEMBL3410218 | 0.79 | IMPDH2 (0.41) | MAPTNPC1BRD4IMPDH2PAK1 | |
| SCHEMBL3412096 | 0.79 | BRD4 (0.46) | MAPTNPC1BRD4IMPDH2PAK1 | |
| SCHEMBL3412246 | 0.78 | SYK (0.42) | MAPTNPC1BRD4IMPDH2PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |