Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 7/20 | 0.37 |
| ▸ | SOAT2 | O75908 | 3/20 | 0.36 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409675 | 0.77 | SOAT1 (0.52) | SOAT1SOAT2ACAT1 | |
| SCHEMBL3412530 | 0.77 | SOAT1 (0.53) | SOAT1SOAT2ACAT1 | |
| SCHEMBL3404851 | 0.70 | NLRP3 (0.41) | SOAT1SOAT2ACAT1 | |
| SCHEMBL3414072 | 0.65 | SOAT1 (0.48) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9765050 | 0.64 | SOAT1 (0.51) | SOAT1SOAT2ACAT1UBE2MDCUN1D1 | |
| SCHEMBL9818587 | 0.64 | SOAT1 (0.64) | SOAT1SOAT2ACAT1 | |
| SCHEMBL9818605 | 0.63 | SOAT1 (0.66) | SOAT1SOAT2ACAT1 | |
| SCHEMBL14236583 | 0.63 | SOAT1 (0.54) | SOAT1SOAT2ACAT1 | |
| SCHEMBL6803622 | 0.62 | NMBR (0.45) | SOAT1SOAT2ACAT1UBE2MDCUN1D1 | |
| SCHEMBL11143056 | 0.62 | ALDH1A1 (0.58) | SOAT1SOAT2UBE2MDCUN1D1PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200979-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2010-06-30 | — | — | EP | claimed |
| WO-2009030752-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-12 | — | — | WO | claimed |