Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409346 | 0.86 | OPRM1 (0.46) | OPRM1OPRD1OPRK1NQO2MTNR1A | |
| SCHEMBL24650903 | 0.83 | MIF (0.40) | OPRM1OPRD1OPRK1MIFHDAC6 | |
| SCHEMBL13047900 | 0.79 | MIF (0.46) | OPRM1OPRD1OPRK1MIFHDAC6 | |
| SCHEMBL3411923 | 0.79 | MIF (0.46) | OPRM1OPRD1OPRK1MIFHDAC6 | |
| SCHEMBL3413462 | 0.79 | MIF (0.46) | OPRM1OPRD1OPRK1MIFHDAC6 | |
| SCHEMBL3413664 | 0.76 | MTNR1A (0.44) | NQO2MTNR1AMTNR1B | |
| SCHEMBL24650269 | 0.73 | NQO2 (0.37) | OPRM1OPRD1OPRK1MIFHDAC6 | |
| SCHEMBL24650926 | 0.73 | MIF (0.42) | OPRM1OPRD1OPRK1MIFNQO2 | |
| SCHEMBL24650907 | 0.72 | SHBG (0.42) | OPRM1OPRD1OPRK1MIFHDAC6 | |
| SCHEMBL3407380 | 0.71 | MTNR1A (0.57) | MIFNQO2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260017-A1 | CONFORMATIONALLY CONSTRAINED CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS | Amgen, Inc (US) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009111056-A1 | CONFORMATIONALLY CONSTRAINED CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING METABOLIC DISORDERS | AMGEN INC. (US) | 2009-09-11 | — | — | WO | disclosed |