Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3409953 | 0.83 | PIK3CA (0.49) | RETAURKAAURKBEGFRFGFR1 | |
| SCHEMBL3407822 | 0.80 | PIK3CA (0.59) | RETAURKAAURKBEGFRPIK3CA | |
| SCHEMBL3409753 | 0.80 | PIK3CA (0.52) | RETAURKAAURKBEGFRPIK3CA | |
| SCHEMBL3409641 | 0.79 | PIK3CA (0.49) | RETAURKAAURKBEGFRPIK3CA | |
| SCHEMBL3412646 | 0.79 | SYK (0.46) | IGF1RRETAURKAAURKBFGFR1 | |
| SCHEMBL3407305 | 0.79 | PIK3CA (0.61) | RETEGFRPIK3CAPIK3CBPIK3CG | |
| SCHEMBL4090918 | 0.78 | PSEN1 (0.52) | — | |
| SCHEMBL3410316 | 0.78 | IMPDH2 (0.44) | NPC1RAB9A | |
| SCHEMBL3410466 | 0.78 | PSEN1 (0.43) | IGF1RRETAURKAAURKBEGFR | |
| SCHEMBL3406106 | 0.78 | IGF1R (0.41) | IGF1RRETAURKAAURKBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |