Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 8/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | MBTD1 | Q05BQ5 | 4/20 | 0.32 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.32 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407514 | 0.83 | EPHX1 (0.50) | L3MBTL1THRBATMCHRM1HRH3 | |
| SCHEMBL8001872 | 0.83 | THRB (0.41) | L3MBTL1THRBATMOPRK1CHRM1 | |
| SCHEMBL4422275 | 0.75 | THRB (0.38) | L3MBTL1THRBATMOPRK1 | |
| SCHEMBL1134286 | 0.74 | EPHX1 (0.56) | L3MBTL1THRBATMKDM4EALDH1A1 | |
| SCHEMBL3408089 | 0.74 | OPRK1 (0.36) | L3MBTL1THRBATMMEN1KMT2A | |
| SCHEMBL4419803 | 0.73 | MMP2 (0.40) | L3MBTL1THRBATMOPRK1 | |
| SCHEMBL4420588 | 0.73 | MMP2 (0.40) | L3MBTL1THRBATMOPRK1 | |
| SCHEMBL5202351 | 0.72 | THRB (0.33) | L3MBTL1THRBATMOPRK1 | |
| SCHEMBL13623033 | 0.71 | KDM1A (0.31) | — | |
| SCHEMBL2382220 | 0.70 | THRB (0.56) | L3MBTL1THRBATMPOLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257543-A1 | MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF 177 | AstraZeneca AB (SE) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009108117-A1 | MUSCARINIC RECEPTOR AGONISTS, COMPOSITIONS, METHODS OF TREATMENT THEREOF, AND PROCESSES FOR PREPARATION THEREOF 177 | ASTRAZENECA AB (SE) | 2009-09-03 | — | — | WO | disclosed |