Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.72 |
| ▸ | NPC1 | O15118 | 6/20 | 0.72 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | GRM5 | P41594 | 4/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.58 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31414959 | 0.85 | RAB9A (0.70) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL6646471 | 0.85 | RAB9A (0.70) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL18979481 | 0.84 | RAB9A (0.52) | RAB9ANPC1MEN1KMT2AGRM5 | |
| SCHEMBL31672285 | 0.84 | RAB9A (0.52) | RAB9ANPC1MEN1KMT2AGRM5 | |
| SCHEMBL29155609 | 0.83 | RAB9A (0.83) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL29366822 | 0.82 | RAB9A (0.89) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL997866 | 0.82 | RAB9A (0.89) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL7189774 | 0.81 | RAB9A (0.86) | RAB9ANPC1MEN1KMT2APKM | |
| Hydrochloric Acid SCHEMBL27681799 | 0.81 | RAB9A (0.86) | RAB9ANPC1MEN1KMT2APKM | |
| SCHEMBL4636673 | 0.81 | RAB9A (0.72) | RAB9ANPC1MEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257539-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009117269-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |